EVALUATION OF THE ANTIEPILEPTIC POTENTIAL OF METHANOLIC EXTRACT OF
CYPERUS ARTICULATUS LINN. IN MES-INDUCED SEIZURES IN RATS
Baddala Poorna Chandrika 1 , B. Ramesh 2 , 1Prabhath college of Pharmacy, Nandyal. 2CES college of Pharmacy, Kurnool.
DOI : https://doi.org/10.63712/bpsrj-v1i2p005
ABSTRACT:
Epilepsy is a chronic neurological disorder characterized by spontaneous and recurrent seizures. The search for safer and more effective antiepileptic agents has led to increasing investigation of medicinal plants. Objective: This study investigates the antiepileptic activity of the methanolic extract of CyperusArticulatus Linn. leaves in Wistar rats exposed to maximal electroshock (MES)–induced seizures. Methods: The methanolic leaf extract of Cyperus Articulatus Linn (EECE) was administered orally at doses of 200 mg/kg and 400 mg/kg for 14 days. Phenytoin (25 mg/kg, i.p.) served as the standard drug. MES-induced convulsions were produced using a 60 Hz, 150 mA current for 0.2 seconds. Various phases of convulsions were recorded, and protection against hind-limb tonic extension (HLTE) was evaluated. Results: EECE produced significant, dose-dependent protection against MES-induced seizures. Animals treated with 200 mg/kg and 400 mg/kg showed 68.8% and 85.3% protection, respectively, with marked reductions in the duration of HLTE. The higher dose exhibited activity comparable to phenytoin