STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CEFIXIME, LINEZOLID AND MOXIFLOXACIN IN FDC TABLET DOSAGE FORMS
Sairam Pebbeti1, Prof. NJR.Hepsebah2, Department of Pharmaceutical Analysis, Vijaya College of Pharmacy, Hyderabad.
DOI : https://doi.org/10.63712/bpsrj-v1i2p001
ABSTRACT:
Cefixime, Cefpodoxime, Cefepime are antibiotic drugs under the class of cephalosporin antibiotics. These drugs are used to treat respiratory tract infections, skin infections and urinary tract infections. Brivudine is an antiviral drug (herpes zoster virus). Conclusion: The present research work described about a stabilityindicating RP-HPLC method development for the simultaneous determination of CEF, LNZ and MOX drug content in CEF+LNZ and CEF+MOX FDC tablets. And the method is validated to show its capability for intended application. Through validation the developed method found to be precise, rugged, accurate, linear, specific and robust. From the forced degradation study it is found that all the degradants formed are well separated from CEF, LNZ and MOX, and it concludes that the method is stability indicating in nature.