ISSUES RELATED TO LIMITED TISSUE PROCUREMENT FOR CANCER DIAGNOSIS IN THE ERA OF INIMALLY INVASIVE SURGERY AND ADVANCED SURGICAL PATHOLOGY
B. Midhinesh, B. Madhu Ranga Swamy, Sri Venkateswara Institute of Medical Sciences, Tirupathi.
DOI: https://doi.org/10.63712/bpsrj-v2i1p007
ABSTRACT:
Recent progress in diagnostic imaging, surgical techniques, and molecular pathology has transformed cancer diagnosis and management. Minimally invasive surgical approaches, once largely reserved for benign conditions, are now widely applied for oncologic tissue procurement. However, the reduced volume of tissue obtained through such procedures often presents significant diagnostic challenges. Although advances in ancillary testing including immunohistochemistry, molecular diagnostics, and genomic sequencing have enhanced diagnostic sensitivity, these techniques remain dependent on the adequacy and quality of the sampled tissue. This review examines the evolving role of minimally invasive surgery in cancer diagnostics, highlights limitations associated with restricted tissue sampling, and emphasizes the critical importance of tissue adequacy assessment. A coordinated multidisciplinary approach involving radiologists, surgeons, pathologists, and molecular laboratories is essential to ensure diagnostic accuracy and optimal patient outcomes